Pathway engineering in Corynebacterium glutamicum S9114 for 5-aminolevulinic acid production
نویسندگان
چکیده
منابع مشابه
Engineering Corynebacterium glutamicum to produce 5-aminolevulinic acid from glucose
BACKGROUND Corynebacterium glutamicum is generally regarded as a safe microorganism and is used to produce many biochemicals, including L-glutamate. 5-Aminolevulinic acid (ALA) is an L-glutamate derived non-protein amino acid, and is widely applied in fields such as medicine and agriculture. RESULTS The products of the gltX, hemA, and hemL genes participate in the synthesis of ALA from L-glut...
متن کاملSystematic pathway engineering of Corynebacterium glutamicum S9114 for l-ornithine production
BACKGROUND L-Ornithine is a non-protein amino acid with extensive applications in medicine and the food industry. Currently, L-ornithine production is based on microbial fermentation, and few microbes are used for producing L-ornithine owing to unsatisfactory production titer. RESULTS In this study, Corynebacterium glutamicum S9114, a high glutamate-producing strain, was developed for L-ornit...
متن کاملA New Strategy for Production of 5-Aminolevulinic Acid in Recombinant Corynebacterium glutamicum with High Yield.
UNLABELLED 5-Aminolevulinic acid (ALA), a nonprotein amino acid involved in tetrapyrrole synthesis, has been widely applied in agriculture, medicine, and food production. Many engineered metabolic pathways have been constructed; however, the production yields are still low. In this study, several 5-aminolevulinic acid synthases (ALASs) from different sources were evaluated and compared with res...
متن کاملEngineering Corynebacterium glutamicum for violacein hyper production
BACKGROUND Corynebacterium glutamicum was used as a metabolic engineering chassis for production of crude violacein (mixture of violacein and deoxyviolacein) due to Corynebacterium's GRAS status and advantages in tryptophan fermentation. The violacein is a commercially potential compound with various applications derived from L-tryptophan. RESULTS Corynebacterium glutamicum ATCC 21850 that co...
متن کاملEngineering of a glycerol utilization pathway for amino acid production by Corynebacterium glutamicum.
The amino acid-producing organism Corynebacterium glutamicum cannot utilize glycerol, a stoichiometric by-product of biodiesel production. By heterologous expression of Escherichia coli glycerol utilization genes, C. glutamicum was engineered to grow on glycerol. While expression of the E. coli genes for glycerol kinase (glpK) and glycerol 3-phosphate dehydrogenase (glpD) was sufficient for gro...
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ژورنال
عنوان ژورنال: 3 Biotech
سال: 2018
ISSN: 2190-572X,2190-5738
DOI: 10.1007/s13205-018-1267-2